By
Sampson I.M Onwuka
We have reached perhaps another
threshold in the studies of Biology and we are looking at the period in
Medicine when the theory of the Human Immune Deficiency Syndrome can be finally
given an official obituary. In keeping
to themes of 2014 August 12th, and the injunctions justifying great periods in
the annals of world history, we can begin from May 15, 2015, to attempt a
public analyses of the theories involving HIV and how it can finally be set
aside for all times. It may not be the case when there are various cases on HIV
stories that need not be repeated but do generate as much enthusiasm as new
breakthroughs in Biology. Drawn from the piece from last year, we can recall
that the emphasis on Polio Virus was the author’s systematic strategy in
analyzing some of the gaps and deficiencies which bar the final solutions and
answer for Interleukin-2 virus and HIV. To the extent that this author
classified HIV as a blood cancer was no new article of faith, it was driven
perhaps by lateral arguments on Lentivirus and the slow Visna viruses some of
which are gradually due to the origins of the strains. One of the flim-flam
from Robert Gallo is the attempt at correlating Cancer or Oncogenic viruses and
HIV, that is Oncogenic and Lentiviruses such Visna develop gradually inside the
cell of the recipient.
In a forward by Bill Clinton to the
book written by - San Francisco, November 26, 2012 - to a new book on HIV/AIDS anthology, he asked the same questioned
we have maintained over the years, “ that when the history of HIV/AIDS is at
last written, what will the final chapter look like?” And former Secretary of
State Hilary Clinton maintained that “…the goal of an AIDS-free generation may
be ambitious, but it is possible with the knowledge and interventions we have
right now. And that is something we’ve never been able to say without
qualification before. Imagine what the world will look like when we succeed.”
Visionaries write the Final Chapter
One AIDS – The First
In an essay on a new book by Neil
Giuliano presented by Andrew Hattori on
the issue of AIDS in a new and recent book, that when the final chapter on AIDS
is written, what will it look like? This provocative question is posed to 15
authors—political leaders, researchers, activists, and pioneers—in How AIDS
Ends, a special anthology produced by San Francisco AIDS Foundation featuring a
foreword from President Bill Clinton.
“Each contributor to this anthology
has been deeply touched by AIDS and each of them, including myself, is equally
committed to realizing that joyful day when AIDS is part of our past, not our
future,” said Neil Giuliano, CEO of San Francisco AIDS Foundation. “How AIDS
Ends captures this forward-thinking spirit and reminds us that when it comes to
the fight against HIV/AIDS, there is no shortage of hope.”
Contributors include Timothy Brown,
Jeanne White Ginder, Cleve Jones, Barbara Lee, Mark Dybul, Paul Farmer, Robert
Gallo, Mervyn Silverman, Diane Havlir, Scott Wiener, LZ Granderson, Hank
Plante, Eduardo Xol, and Neil Giuliano. They share their unique perspectives on
the HIV/AIDS epidemic, their visions for how it ends, and who they will
remember when that day comes.
“When we finally defeat this
disease—hallelujah!,” writes Jeanne White Ginder. “I think on that day, I will
feel that Ryan did not die in vain.”
“Now is the time to write a new
chapter in the triumph of hope over despair and love over fear and hate—a new
tale of the wonder of the human spirit,” writes Mark Dybul, the newly appointed
executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria.
“When the AIDS epidemic ends—when
we have a vaccine to prevent new infections, and everyone who has HIV can
manage it with drug therapy—what a joy, what a relief,” writes Dr. Robert
Gallo, one of the co-discoverers of HIV. How AIDS Ends is published as a
digital book and is available through Amazon and other online retailers for 99
cents. All proceeds from the book will be used to support the free HIV
prevention and care services of San Francisco AIDS Foundation that improve the
health of thousands of people every year.
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Some of the assumption can be
reduced to the schools of interest that make a difference between and
Dogma for HIV
- It is translated from one person to another through blood and sexual contact showing signs of Rash, Kaposi virus – Michael Gottlieb,
It does not transfer from one primate to another – Sampson Onwuka
It is a lentivirus – it kills slowly and separate itself from Oncogenic viruses because of the Interleukin 2 – Luc Montaigne
- It is an oncogenic virus and show patterns conceivable close to a strain of cancer which seem parallel to a strain of monkey virus from Zaire - Robert Gallo
- It is a blood Cancer comparable to the – Sampson Onwuka
- It refrains from DNA of the host and does not have personal DNA and it has two pieces of RNA – CD4 and Retro-virus – David Baltimore
- It is Thymus depended – a general dogma and has a tendency to use E. Coli and Streptococcus
- Its formative origins may have started differently – perhaps male to male – primary productive isolation – Sampson Onwuka
- Vaccination is Contagious – and probably unsafe – Prophage and Age of Bacteria – Sampson Onwuka
People do not necessarily die from HIV, they die from opportunistic infection – general dogma
HIV virus is not the only immune deficiency syndrome, auto-immune failures can be induced by drugs and
Use of AZT and other drugs may be useful in decreasing the Course of the Virus and not the rest…
Put it clearly, we must necessary
understand that the process and complication of thymus as a sugar complex ; the
CD4, the penetration of the human immune system by locally manufactured foreign
virus (HIV) and the gradual evolution of a prophage whose life retains a DNA
from previous reproductive process gives us the impression of Immune Deficiency
that is determined by the ability of existing DNA and genetic substance –
Cytosine, Guanine, Adenine and Thymine, and here we can easily lift from
Genetics Home Reference the following definition, that “DNA bases pair up with
each other, A with T and C with G, to form units called base pairs. Each base
is also attached to a sugar molecule and a phosphate molecule. Together, a
base, sugar, and phosphate are called a nucleotide.”
So together, a base, sugar, and
phosphate define nucleotide, and from well-rehearsed arguments from last year,
the finally parted ways role of Thymus is rebuilding human DNA, that the
complex breakdown and regeneration of life was considered a well distributed
responsibility among the primary chemicals but like Bromide-5-Methylation, the
process of adapting the body to new realities is something achieved by Thymus
or CD4s. The author also identified the particular kind of sugar dissolving
bacteria that can considered – part and central to these process – especially
the introduction Avery Oswald, Alfred and Martha Chase well received
experiment, perhaps with reason and succinctly by French scientist Andrew
Lwdolf, Jacque Monod and Maurice Francoise, especially Jacque Monod and the
emphasis on E.Coli.
If suggest that the title of this
essay and in fact one of the more important essays of our generation should be
'Kicking the Ass of AIDS' but we shall open up on this topic by citing that
Human beings have always found themselves challenged by all plaques since the
beginning of time, that the great advantage of our time is the new techniques
and new machines are being used, and are to investigate on this virus and are
sometime successful in discovering of the agents responsible for these new
virus and infection.
In this case, the point that
“…increasing evidence points to hypersensitivity reactions of the immune system
to antigens or the candida surfaces or the metabolic products of the organism…”
will attract some new explicating since the latest ELISA test and the earliest
ELISA test as based on the reactionary tendencies of the CD4. It does not mean
that ability of any Fungus to evade the body relapses into the penetration of
the body by the cell and the fungus, including its pathogenicity; how its
penetrates and what regions, that it makes to the blood streams (Se….?) later
argues for a late onset which from its earliest beginning did not begin through
the blood stream.
Assuming the fungus-like structure or the bacteria with the
hints of fungus such as Candidiasis – although mainly if not exclusive from
plants hence a construct for fungus – penetrates the walls of the body by
action and help of histamine that naturally help the penetration of the walls
of the cells since like CD4 they operate on the surface, would mean that the
IgA through IgE gradually mount reaction to this fungus in such a way to
suggest that structure travel first from IgG less environment since this
particular kind of antibody only surfaces in the life on a child after the
first 6 months within which Candidiasis generally penetrate the child’s system
failing to fully show its given the hundreds of other bacteria that reach the
child as well.
HIV is a virus that invades the
body is an infection largely for what it does over time to it, that it can
weaken the immune system is a fault that is not exactly of its own making. It
is therefore necessary to incorporate some of the assumption in the piece by
Deusberg that the some bacteria do in fact remain dormant, and here confirmed
by the authors of the Magic Shot, these viral bacteria affect passing a process
of chromosomal exchange, end up producing viruses that are familiar with a
system. In this case, we invoke the thesis in the earlier our earlier
composition that perhaps second premise, that the Virus may have started its
journey as something other than virus but gradually ended as dangerous to the
system due to changes that gradually take place when the CD4 is said to be at
its lowest end.
In some measure, the role of viruses entering the body either
through the mouth which is usually the causeway of most live virus into the
body are naturally arrested by Alpha Globulin IgG, which mount the initial
defense in the body and along the respiratory tract and into the gut of the
intestine and mucosa, and they are usually found in the tears, in mucus, and in
the intestine where they confront the new arriving viruses, but then the body’s
lymphocytes and lymph cells produce proteins called Igs, Igm, that gradually
react to these new arrivals and are mostly found in the blood, then it
moves….the last of these immune-globins are the biggest and these are the
arresting houses of some of the bacteria that die naturally or forever
perpetuated in the system through the control of the cells.
List …….
From the above instances, we can
conclude that some of the changes that arrive at the Candidiasis or the
earliest immune related to ‘candida albicans’ and sometimes by other species
such as C. Trophicalis which are naturally supposed to be harmless may become
virulent affecting several parts of the body, invading the cells, including
some of the mast proteins and basophils, creating conditions of osteomyelitis
(muscle-skeletal disorder), skin rashes (some of which are comparable to
Sarcoma), whacks the central nervous
system (meningitis),…..“Because Candida are normal members of the body’s
microflora, their presence on mucous membranes is tolerated by immune system,
and the inflammatory reaction induced by hypersensitivity response becomes a
chronic condition. This reaction may remain local, at the site of dense
colonization by the organisms, or became systematic and affect any organ system
in the body.” (Joneja, Bielory, Understanding Allergy). Allergic reaction to be
sure is triggered by many things in the body, but when there are instances of
chronic candidiasis caused by Yeast-like fungus usually remain dormant from
birth but gradually and eventually reappears when there is a less presence of
the cells that control them, for instance in the case a competing bacteria all
of which attack people from the earliest years of the child conception and
delivery to about 6 months after delivery. It is the presence of some of these
bacteria based complexes in the body, many of which reach the newly born from
respiratory tract that compose the transfer and translation of these bacteria
into highly favorable and systematic protection that the body needed.
The Arrest house of the lungs
raised from Verghese points to this very fact that various diseases are kept
under arrest by the body and y the actions of the Chromosome 8 until the
defense system is broken to the point that the body can no longer synthesis,
split and condition these viruses. This
example in the way they cited in this account do not fly in the face of other
accounts or in the presence of the claims made by Verghese, regarding the
introduction of Cortison into the body whereas it enables the body to fight off
cold of some types, it leaves the body essentially vulnerable to increase in
bacteria and fungus once dormant in the body. This results from the depression
of the immune system by the immunogenic, unlike the type I, type II, type III
and type IV, defense mechanism we regard the structure of the cell and its
ability to manufacture immune-globin and its response to foreign antigens are
reactions that are derived from the presence of the lymphocytes’ protein and
the reaction time necessary for the body to overcome.
Using the example from Joneja, Bielory, the
ability of Candidiasis to make this comeback in the body is due in this case to
combination through types of defenses the body could mount. That in the case of
the fungus-like structure of candidiasis it has the ability to withstand the
first round of the attacks by the body, usually in the intestines and the
rectum, for here the body’s first lines of defenses are in the mucosal where
histamines that help to embellish the chromosome and the actions of the CD4 in
the body, play a hide and seek game with what looks like Mucous in the body, hence Candida which ‘…are normal members of the
body’s micro-flora…on mucous membranes is tolerated by immune system, and the
inflammatory reaction induced by hypersensitivity response becomes a chronic
condition.’
There are from earliest entrance into the body of the child part of
its mechanism, to the point that their reaction to the system is based on human
less the body tolerates them, depends on the presence of competing bacteria and
foreign antigen which Chromosome 5 is very good for – at least towards
conditioning their own complexes hence composing the degree of tolerance by the
Chromosome 8 and the human immune system. These exposure that a child has a
young age is perhaps good and bad, would not have mattered where it not for the
tripping in the defense system, some on account of the cold virus and the
other, on account of the presence of other chemical element which the body
naturally produces. Brightly speaking, even a sugar complex may create serious
immunogenic havoc when in excess composition in the body, and when the body can
manufacture.
Here we paint a quick brush stroke
on the early papers on this virus; New England Journal of Medicine published in
1981 with title “Pneumocystis’ Carinii Pneumonia and Mucosal Candidiasis in
previously Healthy Homosexual Men – Evidence of a New Acquired Cellular
Immunodeficiency.” This caption more than explains the convulsion involved with
the new virus, it throws light on what they consider to be the more evident
….with the virus, that it is above all ‘...a new acquired cellular
immunodeficiency’, means that other forms of immunodeficiency were not unknown
and not unfamiliar with Sciences, that it means to suggest that was exclusively
common among Gay at the time, admits the problems of demonstrating that among
the early cases were Haitian immigrants. However the weight of the material in
Haiti was no nearly as profound as it became some time later, that it means to
suggest that Haiti got a fair shake for allegedly harboring the killer virus,
also throws some light on what early theories could really do in the later
studies on a virus and its pathology.
Playing backwards it is impossible
to deny that these movement of a single celled fungi and a single celled
viruses, could not support itself own existence saving that it attached itself
to the host, that in spite of what we now know as the difference between the S
strains of some bacteria and R strains, there is something about DNA and RNA
that separate a virus from a bacteria, something about the RNA to RNA dogma familiar with transcriptase that
will point to the existence of two separate viruses enclosed in a what is
called HIV nucleus capable of supporting itself through the enzymes, operating
as if it was a multi-celled that is more than one virus and since the virus and
the Amino Acid of the HIV is RNA+ are said to profligate but less than the vicariate
and hierarchy of a bacteria, it means that the retro-virus of HIV explains its
own history, that life became as a constant addition of two probable entities –
the root of which is perhaps the trapped hydrogen determined bonds of a DNA
which is itself perhaps two RNA of some unofficial verity.
The Special cases such as
Hepatitis, adenovirus, Coxsackie, varicella, human herpes virus type 6
(HBLV-6), Cytomegalovirus, Herpes Simplex type I, and measles, for these
isolated groups of interesting infectious disorder, are well studied and have
easily occupied the time of medical communities in the world. Some of these are
no longer the first light on the concern of big world organizations such as the
UNID, MAP, and the engaged efforts of NIH in Maryland, there are other concerns
like those of Malaria which has been reported to have claimed more live than a
more primary problem of HIV, and the foundations such as Bill and Melinda Gates
Foundations have added luster to the efforts in eradicating Malaria parasites,
to providing new tools for vaccines in India on the final notes that Polio is
eradicated.
Several measure of efforts on HIV
including international corporation working for the general good of the world,
are variously involved in the pursuit on new curative for viruses such Ebola
which is also recent, viruses such as Measles when and if they occur, and the
permuting need for orally delivered live-virus, BCG which the French developed
and MMD, which the English developed, along the vaccines here in the United
States, part of which is the saccharine and starch passaged and tested cold flu
viruses, authored in the United States every year.
In one case worthy of the trouble
is the recent breakout of Ebola which is reasonable close to the instances of
Lassa Fever - not unlike Yellow Fever – are different on account of the source
of these viruses; the first seem to have arrived from Rats and the Second from
Mosquitoes, and are quoted by foremost authorities on the subject to have come
through Africa. All the named variously are known to have reached United States
through Africa and Africa for this reason has been the interest of preeminent
scientist of the world.
In Robert S. Gottfried ‘The Black
Death’ which was set in order of F.A Gasquet 1893 ‘Black Death’ we find him
discussing that “Important as small pox and measles were in the natural history
of infection disease, their combined role was dwarfed by the arrival in 541 of
a third disease. This was plaque caused by a complex series of bacterial
strains called ‘Yersinia Pestis’”, he went on to argue that the Plagues
etiology demonstrates ‘Y. Pestis’ toxicity varies, but the diseases is always
highly lethal.’, that it lives “it lives in the digestive tract of the host
“black flea” while feeding regurgitates into its victim large numbers of Y-Pestis
bacillis.” In the end, we find that people’s inability source the mode of
transmission of the Bacteria into the body made them prey to the dangerous
nature of the killing plague which devastated Europe from 1347 – 1351 and
killing up to 25% of the population.
It was most probably inhaled and in
recent times, at least at the turn of the 20th century, there was a similar
outbreak of Cold Virus resulting in the body of its victims turning blue-black.
This Influenza wiped off the people in the Ship and their boat never made to
ground and died every one of them on board. The Ship was discovered in some
abandoned placed, half docked and crash landed. Someone mentioned that the
silence of the crew which included renowned doctors of import….It is possible to
suggest that relationship between these kinds of Virus and Bacteria is that the
Bacteria are single celled organism that needs oxygen to survive on its own. It
can also spread as rapidly as any
Robert Koch settled the issue of
Diphtheria, discovered the virus that caused Tuberculosis, but in 1892, in the
United States it was Walter Reed that discovered that Yellow Fever is
transmitted through Aedes mosquito, and according to Rita Mary King ( ), by the
end of that decade, Joseph Lister in England developed aseptic to prevent
infections.
Molly Caldwell Crosby 'The American Plague'; 2006, 'the untold story of
Yellow fever' for instance describes the problems with the victim’s body as
this that "The Virus attacks every organ, poisoning the body from the
inside out. As the immune system fights back, temperatures run as high as 105
degrees, and the patient grows delirious. The body gives out. It hemorrhages,
running red from the eyes, nose, and mouth. Vomit, black with blood, roils.
Then, the fever leaves its mark, tinting the skin and whites of the eyes a
brilliant yellow, giving the virus its infamous name; yellow fever" This
paragraphs is by many designs derived sources which were popular about Yellow
fever and what she however adds to the story is the dynamics of the Virus from
purely academic point.
Rare cases of yellow fever in our
time are hard to come by and the virus seem to have passed from Mosquitoes
carrying a fever virus called Flavivirus from supposedly West African country
and spread among the people in Mississippi. That once inside the body of the
victims, its hijacks the cell and its 'basic machinery' and would use the cells
dynamics to "replace the Viral proteins and RNA, until the particles burst
through the cell." In no distant time a body full of healthy cells would
in no time be riddled with virus carrying the 'yellow fever virus' and for this
process "anything that could destroy the virus might also destroy the
cell", she said.
In a World Health Organization rap sheet on Malaria transmission and the
Malaria causing Mosquitos; January 14th, 2014, the sheet, clearly pointed that
“Malaria is caused by a one-celled parasite called a Plasmodium. Female
Anopheles mosquitoes pick up the parasite from infected people when they bite
to obtain blood needed to nurture their eggs. Inside the mosquito the parasites
develop and reproduce. When the mosquito bites again, the parasites mix with
its saliva and pass into the blood of the person being bitten.” The sheet
continues that “Malaria parasites multiply rapidly in the liver and then in red
blood cells of the infected person. One to two weeks after a person is infected
the first symptoms of malaria appear: usually fever, headache, chills and
vomiting. If not treated promptly with effective medicines, malaria can kill by
infecting and destroying red blood cells and by clogging the capillaries that
carry blood to the brain or other vital organs.” These symptoms of the body
over-powered by these mating Mosquitos it’s not the same in every person, does
not also affect anybody in the world, like the saying goes in Africa, Mosquitos
do not even bite everyone at the same rate.
It has preference for blood types, and the
rate at which it mounts proboscis on any person sometimes measures the level of
demand for a person blood type, that those with classic A Antigen blood group
are more than likely to suffer from these attacks from plasmodium, a relay that
like Red Bugs and Bed Bugs, the bites from insects can be due to a blood type,
and the reaction to these germs in the body can also be brutal if not demanding
to such persons including consisting scratching of the hands and the legs or in
facial irritation leading to headache. The rest of the problems that warrants
death is the failure of an active T Cells from matching the replication of
these germs in the body, at a rate that suggest a mature germ which must feed
on the host ridden from body of the Anopheles to a different host, in exchange
of a blood from such a person.
In all reality, the structure of a
HIV positive RNA is digestible by an anopheles that the connection to
Plasmodium is not warrantless lead search towards understanding why the HIV
attack Plasma, both pathogens or parasites are dependent on Plasma, but the
Plasmodium induced Malaria, it’s in all, a foreign entity, that may paralyze a
victim for a few weeks but not permanently locked in pitch battle like HIV.
“There are four types of human malaria: Plasmodium vivax, P. malariae,
P. ovale and P. falciparum. P. vivax and P. falciparum are the most common
forms. Falciparum malaria—the most deadly type—is most common in sub-Saharan
Africa, where it causes nearly a million deaths a year.”
“In recent years, some human cases of malaria have also occurred with
Plasmodium knowlesi – a species that causes malaria among monkeys and occurs in
certain forested areas of South-East Asia.”
In account that shed weight on chain
of discretion from older times to now, we may look at the work of Tsetse Fly,
and the direct association of the a fly to the introduction of trypsomania to
the body which when transferred to second body, causes the blood sucking
pathogen to feed on the Red blood cells leaving the victim seek and weak, to
the point that the furious replication of the virus in the body led to weaker
and weaker immune system and eventually to the death of the patient who was
recently infected.
The Colonials in parts of South
Africa who died in some numbers because of these diseases were privileged by
their education and by the use of stethoscope to fight back on these killer
diseases and in this case, there was a certain David Bruce who came fresh from
the wars on Crimean fever which was the course of the Malta fever where he
isolated a bacteria ‘Micrococcus melitensis’ from the spleen of men who died
from it, to Africa on assignment by the English Majesty.
The main event was discovery of the
source of Tsetse fly and where he isolated the agent for it. John Mckelvey,
Jr., (1973) makes out this history, revealing that the commission to go to
South Africa led him to discover that “the Haematozoon or Blood Parasite of Fly
Disease” which left what we know as fragment of its DNA on the host, and the
DNA proved a blood sucker which the fly essentially retract upon maturation. Here, the examples followed by Bruce David
were those of Karl Joseph Eberth, Edwin Klebs, and Robert Koch, and in his time
was said to have produced the Sodium B-aminophenylarsonate- NH2C6H4A5O(OH)ONa,
all in other of a quinine manufactured by Klebs to counter the diseases
malaria.
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