By
Sampson I.M Onwuka
It will seem also that the
comparison between the Lentivirus that Montagnier is associated with is not
unknown to Gallo, promotes only two possibly arguments that Robert Gallo were
looking at the comparative physiology of the primates and the humans, their
gaps in defense mechanism and whole comparative physiognomy, that he believes
in lieu of Rockefeller Institute and their historical breakthroughs, that a similar
virus if discovered in the primates can lend a pair of eyes to those of humans.
The second reasons are that he and
his group may have believed upfront that the virus essentially came from
Africa. It is only reasonably reassuring that Interleukin-2 associated thymus
which Montagnier emphasized has its reasons, based perhaps of Claude Jasmine
Chermann.
Therefore a connection between the
cancer virus and human immunodeficiency virus were test that led to wrong
conclusions, for if HIV in of itself could infect monkeys, a kind zoonotic
trans-infection would be possible among the humans. Looking at the conflict in
the early years between Gallo and Montagnier, it is becomes gradually clear
that Montagnier or the house on which Montagnier is based would have collapsed,
were it not for the fact that he did specifically mention that he used the
Interleukin-2 protein induced virus to isolate the HIV virus, suggesting that
he was right that the virus called HIV or initially a LAV virus was different
from Gallo’s Virus.
For the similarity and differences
between Gallo and Montagnier, it will be common sense to show that cancer is
the bottom line in whole argument, while the Gallo cancer causing virus is
different from Montagnier is perhaps due to their specific origins. Although
there are other viruses that trigger the creation of mutants, the rate at which
we notice the differences between the two scientists is what their viruses do
inside the body. HIV can be called a kind of cancer; perhaps blood cancer given
the long held observations of people with the virus and may have been the
motivations behind the use of cancer agents with direct reference to the blood.
But it is the blood that matters,
what happens to the Red Blood cells over time which ends up affecting white
blood cells or CD4 counts over time. A dip in the CD4 counts eventually
comprises the body’s defense systems. We are now certain that AIDS patients die
from Opportunistic Infection (OI) and not from HIV itself. Looking at the
history of HIV from these schools will arm with some basic understanding on why
emphasis on thymine very central towards the survival of the patient, and why
most efforts in correcting the reverse transcriptase did not perhaps lead to
any new grounds.
Here it will be rewarding to show
that mycobacteria is not a new name in the market, it is has been and for many
scientist for instance Lynn Marguilis and her colleague Dorian Sagan, have
given some academic devotion to the transformation that take place in the life
of a bacteria and how these mutational changes, from one area of the
chromosomal to another adds meaning to what is now called Epigenesist which...,
and which Adesinine and Guanine based protein building on a three level
phosphorylation within the cell and through diacyglecrol perform separate
respiratory function relative to the ions of the surface, where a short and
misconceived attraction and relapse duration(cell respiratory on the Golgi
body) can affect the false release of information and trigger event reaction
from the cell are based on some role of oxygen. If we recall briefly the
experiments of Oswald Avery on pneumococcus, there is an express that he
defined about Deoxyribonase Nucleic Acid (deoxyribonucleic acid) there he
emphasized thymine as operand towards the creation of new DNA.
some multi-celled organism living
in the gut of say Cow or in its intestines, which are naturally used for the
reproductive processes of a milk (bi-product) are not normally known to be
destructive, may remain friendly in the gut and intestines of the Cow or other
mammals until the frequency of the cells or immunogenic is comprised….It is
these two viruses that are equally significant in the defenses and failures for
and against HLTV virus which are generally oncogenic such as the ras and abl
and to some arguable degree yes genes in blood and pneumonia related cases can
be represented as viruses received from several range from bare-back viruses
such as mycobacterium, particularly Avian which is a Sars virus which is
respiratory based virus and in like viruses or multi-cellular organism and
their viruses….
Flossie Wang-Staal researched with
great success of the structure of HIV, and it was the knowledge of the
transcription factors acting on the HIV, especially in the introns and
enhancers, the terminations point of the Amino sequencing that provided the base-board
for developing AZT, which implies the phosphate roles of thymine and was set
then without knowing against a alu genes. The marking in terms of the
transcription factor largely because HIV is replicated at the right of the LTR,
but seem by its transcriptase to have perhaps started its origins at the left
of LTR.
That it is no use and cannot really
affect humans as such the placement of the virus at whatever angle and its
conjugation to the nearest human cell which replicates at the right of LTR as
with Amino Acid, prove to be well meaning for a healthy life of a cell, but
this key location could also transduce a mutation leading to cancerous edifies
or creation of mutants. This in-of itself can induce cancer causing deficiency
in human beings and has means and ways of
expressing itself in human beings
as primates – with or without due respect to the Alu genes.
For all intended reasons we presuppose the
methyl alu genes is a jumping genes that is not insubordinate to mutations, and
should be classified as mutagenic. Alu genes are relatively twisted does not
mean they are retrovirus or retrograde, but there are reasons why these twist,
they reveal a different version of the genetic DNA especially among Africa
Blacks. It is suggested that this is part of their evolutionary past is prove
to the causal link between the past Great Apes and the present but these are
alu are not formed in the Great Apes and not prions or dangerous
The man who whose theory on
defective proteins and prions, whose work transformed our knowledge of prions
is Stanley Prusiner. Whether the constipation of the alu genes or the jumping
genes that confirms Stanley Prusiner (U.S) long lived Noble Prize on Prions as
infectious proteins, we are clear that infectious proteins are mutagenic and
does not inspire a transformation from one form to another, a saturated
argument anyone can make saving for the vast implications in phage studies.
For sure if in more recent times, that Arjit
Varik and Elaine Muchmore in trying to adapt a new drug to enzymes working to
oppress the profligate of HIV did not award much help, there is then something
wrong in the process, a misleading grasps of the fundamentals of molecular
biology or in recent times, RNA sciences. “By 1998 Varki knew why we were
peculiar; a 92-letter sequence was missing from a gene called CMAH on
Chromosome 6 in human beings, a gene that codes for the enzyme that makes
GC.” ‘Right in the middle of the
sequence was an Alu genes = ‘Jumping genes.
“So sometime after the divergence of the human and chimp lineage, this
Alu had done what it does best, which is to jump into the CMAH gene, swap
places with the older Alu, and accidently remove the 92-letter chunk of the
gene while it was about it”
‘Throwing stitches’ using his exert
quotations, Matt Ridley stated that the “Hox genes are the recipes for proteins
called “transcription factors”, which means that their job is to “switch on”
other genes. A transcription factor works by attaching itself to a region of
DNA called a ‘promoter’, where IGF2R gene on Chromosome 6 ‘Premature damage to
the brain or late development…
AZT as described by many experts is
cell mediated immune response where AZT is incorporated into the host cells,
DNA, and as Irwin Sherman suggested it is shown to be introduced in some
numbers in the DNA which is set to clarify what Peter Deusberg mentioned that
it actually tampers with your human DNA, whereas the Factor VIII mentioned by
Deusberg is not exactly anomalous may prove to be relevant to Hemophiliacs…..
On AZT a ground breaking theory, we
have noticed the work of other experts such as M. D Grmek (1990; translated by
Russell Maulitz, Jacalyn Duffin), that points out the evolution of the disease
in six hierarchical stages and according to the maturation of its protein,
which for the author reflected “the chorological and biological status of
infection…” and it is A, T, G, and C, that make up
DNA…..3-azido-3’-deoxythymidine – or AZT…., the Antigen-presenting cells and
whose Human leukocytes, Storm trooper T cells antigen (HLA), Viral antigen,
T-cell receptor (TCR) and in one major combination shift from basic complex to
defense mechanism – more like the age of protein, with age protein perform
different function in human body.
Dani Bolognesi, the whole structure
of HIV protein fell, with one particular emphasis of the gp120 envelope
glycoprotein. This gp 120 proved a deciding mark in the renewed assault on HIV
sometime in 80’s and it revealed considerable presence of what he called ‘main
proteins’ (P24/25 inside of the protein box, and gp120 and gp41-43 outside)
whereas some of the proteins are well to share comparative similarity with
sooty mangab1ey (cercocebus atys) which carried a strain of the virus (STLV –
IIIsmm) inside.
In relation to these strain of
viruses, there are lengthy….Grmek as one the foundation members of the war
against HIV mentioned understanding the cleavage enzyme that was delayed in the
orchestration of the CD4, and the primary.
Daniel Bolognesi continued that ‘To
this end, biological modifiers of the T-lymphocytes, such as
interleukin-2(IL-2), hormones derived from the thymus gland, or thymomimetic
drugs (DTC, commercial name imnthiol), were tried, as well as transfusion of
HLA-matched lymphocytes or even bone marrow transplantation.” Emphasis – even after some decades on HIV is
thymomimetic drugs which sometimes prove poisonous given its
“The first of these products
autoimoniotung state or HPA – 23 (so named because it was the twenty – third
heteropolyanion synthesized by chemist Gilbert Herve and Andre’ Teze), was
known ever since 1974 work of Claude Jasmine Chermann as an inhibitor of
reverse transcriptase in the retrovirus responsible for murine leukemia and
sarcoma. Chermann studied its action on the AIDS virus. HPA -23 inhibited the activity
of LAV reverse transcriptase in vitro.” And for this breakthrough studying the
reverse transcriptase is greatly advanced, has dominated a lot of studies in
this respect excluding gene therapy in very recent terms.
The impact of HPA 23 in reversing
elemental LTR Amino replication center including the P. 53 for cancer with
respect of the age of the cells (telomeres) never papered as accurately as the
promise of reversing the reverse transcriptase of probably trapped bacteria
prophage in the evolving chromosomal based (HIV) Viral RNA. The understanding
that genes sometimes trip the activity of Amino acids is a well-established and
grounded biological induction, especially manifest in the attempt of showing
the physical-chemical properties of cells and their lopes which on the surface
are controlled by the transport of energy information and by default oxygen.
Although the uracil (urea) is the
set aside as the element that it responsible for the beginning of the process
of all biosynthesis with look-alike bases comparable to phosphate-methyl 5,
most common of which is thymine, it is for this that elements containing uracil
with the 5th position as bromo-uracil usually translate in the second stages of
the sugar complexes wrong information, since the mutant protein or bacteria
that break them the coupling polysaccharide is turned off or at least
considered mutant, and therefore cannot profligate at the essence of enzymes
that dissolves sugar complexes.
This alone along with activities that result
from the excess lysogenic activity does affect the replication of Amino Acids,
may help in editing some of the information between RNA and DNA, may repay
false RNA to RNA, but may not probably trip the genetic activity resulting from
the rest of body but eventually affecting HPA 23. In essence, this attempt by
Chermann to inhibit the profligate of the VIRUS through arresting the activity
of the binding reverse transcriptase, may involve the artificial introduction
of thymine – which essentially aids the cells to control the activity of
dictated foreign antigen.
Michael Bishop and Harold Varmus
discovered that “virus-encoded oncogenes originate in eukaryotic cells.” But it
will be the Gallo team that will make the better of this theory, and if in the
decision which lend meaning to how some of the theories of oncogenes that
dominated the early and later stages of Baltimore is placed on the same context
as Gallo as he presented some of his assumptions.
That “The HIV dissidents could see
two fundamental problems; HIV was a retrovirus, meaning it should not kill the
cells it infected, and the virus could barely be detected even in late-stage
AIDS patients”, Deusberg (2003) which threw its own light in the context of
well understood realities of the Virus and why it remains part of the human
body in spite of the drugs released to deal with it…..
Although Deusberg and
company need to place some faith in the assumptions raised by the two leading
schools of Gallo and Montagnier, the later holds more promise but Gallo may
have struck an ideal comparative between the operational dynamics of a leukemia
virus – perhaps in the discipleship of Stanley …..and his prions which are
destructive proteins which also have origins somewhere else, and still for
reasons not exactly clear is short of the right stuff in fishing the left and
right of HIV when the CCR5 is knocked out in experimental relocations of the…..
In the event that some worrying
castigations on the number of failed vaccines – at least well-meaning 20
vaccines - can be left to the primitive carousal of a CD4 protein inhibitor by
name nef so named by the company that identified the proteins which HIV DNA
based do not produce, it may not escape our mind that the intrepid connection
between the SV…..In one Deusberg’s exertion’s “AIDS is not a disease. Instead,
the AIDS Syndrome is a steadily growing collection of (currently) about thirty
“previously known” (old) diseases.
Surprisingly in view of their
notoriety for AIDS definitions, It is
true, however, that the incidence of AIDS diseases has increased dramatically
in the 1980’s as intravenous drug use has increased and as both the consumption
of recreational drugs used as sexual stimulants and the use of AZT as antiviral
drug have increased in male homosexuals….”, may true to a large possible
extent, that the problem of HIV viruses, as they apply to Deusberg theories, is
not necessarily the lipid bi-layer of its outer shell which duck the human
cells containing CCR5 receptor, which also promotes the second attachment between
the Virus and the ducking CCR5 from the HIV virus.
Leads to some conclusion that
emphasis on the viruses on the context of its ducking technique is only correct
by some extent alone. That the problem of the Virus is not with outer most
cells, it is with core-protein of two split Streptococcus placed some arrest by
some CD4 who origin can be buttressed by the core-protein of HIV protein
structure, showing that it is operation at a DNA viral level, would not
naturally mature into adult Streptococcus, that is splits ends RNA+ virus whose
primary existence is the B> bursar cells that is similar in composition
Amino Acid from more older cell wall controlled and depended interactive from
and mononucleosis as presorted in Cytoplasm during meiosis, that it farcically
relocated in the human cells which re-dominates the virus, controls but does
not effective destroy it. It looks that the Streptococcus is one the few
capable viruses inside a human cell that profligate by relative contrast
between the Amino Cells,
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