Ending HIV 2015 - (IV)

By

Sampson I.M Onwuka


@Uhuru for new drug treatment of HIV

Russia warns of HIV explosion in the past 5 years with the estimate reaching 2 million positive.


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By

Sampson I.M Onwuka (2014)

David Suzuki and Peter Knudtson on G-6-Pd and job related anemia point to histone and the expression of Chromosomes. That “For example, a disproportionate number of sperm cells of male workers exposed to an individual chemical called 1, 2 – dibromo-3-chloropropane (DBCP), known to cause sterility in men, have an extra Y chromosome resulting from nondisjunction during meiosis…”

Y chromosomes are not easily digested would look the part of interpreting the dysfunction of a mutant protein as similar in composition to the Y sperms reintroduced into the body. It is not exact the case but the extent that somewhere in the ‘code-script’ used crudely by Schrodinger in showing that the full structure of human body are products of a system that essentially repeats on its scripts or forms, that over time, the smallest conspicuous elements retaining these code-scripts or what we call DNA, essentially give rise to a super structure. It is true that the smallest pieces of human body may retain the DNA that provides its own history. But there is a different between a DNA and RNA in such category as that we relate the ability of a bacteria or multi-celled organism to retain its DNA is based in large part on its ability to retain its Chromosomes in the body of its host.


There are several blood types and measures in medical sciences that require the transplantation of one body to another, for instance the transfer of lungs from one body form to another, requires correlation to blood types to the extent that one’s immunology can react to the plasma used during transplantation. But this relative reaction of the body to new substances leading to Cancer and auto-immune reaction do not in reality affect the body’s DNA composition.

The same cannot be sued of the bacteria or a multi-celled organism or in some case Viruses. Bacteria can affect our Chromosomal inheritance by being parceled to the next generation following its injury to the gene. To the point that a genetic material passed from the parents to offspring may have resulted from an injury inflicted on it by the latency of some organism. In reality, there is possibilities of replacement of the affected or damages genes after mitosis when there are more than a spare of healthy genetic pool, but some combination between the two parents does not have any spare to replace it and the damage to genes is carried over to the next generation. It is not also what blood can deliver, some of the blood treatment are realized means of temporarily healing the body, some blood transfusion – the best blood ; the high density – are used for temporary treatment and are eventually replaced by reproductive ability of the host body.

As such a continued injection of blood for some sickle celled, or those with familiar and unfamiliar blood conditions, may only temporarily offer relief of such conditions to any race or to an individual. In the end, the host reproduces its own blood and means. Arbitrary means such as Iron based immunogenic (which helps to manage the transportation of oxygen in the blood, necessary for prolonging the life of HIV patient due in part to the diminishing thymine or T-cells whose roles are intertwined with interleukin separate from Glycerin (visna) and Serine (bovine) lentiviruses, all of which result a diminishing of blood sugar; galactatosade base, lactose, and improper release of oxygen leading to collapse of cells walls hence a deficiency of oxygen bearing hemoglobin and an onset of auto-immune failure from a faulty and pre-packaged three-dimensional Red blood Cells which drives the body’s reproductive and immune based ability, whose profligate ensures the survival of the plasma; the engine of life) and sugar based complexes (enzymes) such as Insulin, are temporary but like temporary relief such as AZT for diagnosed HIV conditions, may temporarily faux with the DNA of the host and when overdose may prove toxic to the body.  

We consider that instance some families with long list of genetic diseases, may carry this genes from one generation to another if they continue to propagate their offspring along same and similar genetic pool. It is with marriage from outside a lineage can they body biologically alter the inheritance. It all probability, there is nothing to ensure that a survival is constant than the attempt to expand the genetic pool of the reproductive organ. To some extent, we may consider that biological conditions are derived from lack of fresh genetic pooling, to the point that many African Americans for instance marrying outside their race may attract a lower and lighter density genes, which may not support their natural sugar production.


Plainly speaking, there is a great problem of diabetes largely from off and on interaction between their high density genes and lower density genes, and when there are obvious cases of high artificial and starch consumption. However, a continued emphasis on a small genetic pool or say lineage who have reached maximum propagation of genetic material leading of a reform of color bases and yellowish appetizing from dermis countering epidermis, may force some of the gene pool from its bearers to retain its damages due to lack of alternate replacement – for instance sickle cell among a variety of the blacks and particular among Africans (Igbos, Bini, Ethiopians, Egyptians, Cameroonians, etc) – may be transferred to a new generation without problems.

But majority of these sickle-cells problems with die a natural death should these group or family with such history marry a few degrees from their core. African tribe such as Igbo to African tribe Yoruba is an excellence example. For some changes in life to become permanent, it is biological science that it should passage through reproductive processes. Does not mean that it applies to all proteins and enzymes especially when they appear as a side-effect from a disease bearing bacteria or virus. For us to place some hope on why the male is perhaps responsible for the birth of the new virus, a more difficult but somewhat intelligible assertion using the operon in E. Coli experiments mastered over 40 years by the America phage group beginning with Luria and Delbruck but essentially clarified in the long experiments of Monod, that between the repressor bacteria and operon, it’s the transfer of material information from one bacteria male E.Coli to a female E.Coli, whereas the reducer (needing less oxygen; the female) is the one that carries on the replication.

 From this easy angle, a cheap interpretation is wholly important is that seems that the discoveries of Stahl and Messelsn’s of the impossibility of Phosphate sugar without oxygen, seem to play that the male bacteria used oxygen its resolution of sugar complexes and in the process enable to consummate on the female.  All properties regarding this transfer of material benefit results on a seeming and possible ending of a process, yet it does not mean that the male bacteria dies, it means that oxygen not unlike the processes involved in addition or removal of oxygen in human bio-synthesis by the ribose Sugar (Deoxy-ribose) is grounds enough for new DNA replication. But it is close since the only process a bacteria can make a DNA is through the reproductive processes trapping and using oxygen and through the use of a thymine based element and probably uracil.

The ability of the body to compensate on this F-factor by the sitting or ducking bacteria is due to the host’s or cell’s ability to regulate the profligate activity of the RNA. It is here all too clear, that majority of the disease based immortalized cells which are able to reproduce on their own, began with the F-factor processes, that it needs be said that replication is female as the inception in complete and profligate which occasional leads to high propensity, to a false attachment and re-awakening of the dormant viruses and bacteria is to some extent male–ridden and may regarded as RNA+. All viruses and bacteria capable of infecting the body are usually RNA+, due in most cases on the truancy of a foreign cell which finds mating capacity in the body of the host and its B-cells (bursar) and which penetrates the cell of the host by ducking its surface using the glycol-protein which link on the present angle of the virus’s cell protein to the host cells and which in the circumstance is permitted to either penetrate the cell through in many cases the link on the CD4 (T-4) and are essentially destroyed by the cell on copulation with sugar and thymus derived T-cells within the surface of the host cell or as they enter the cell’s nucleus with their foreign DNA.

The HIV virus is proven capable of evading not only the host cells which it interrupts leading to early signs Symptoms of the viruses including Nausea, rashes, headaches, Kaposi Sacoma, which we would have learned by now, are the bi-product of a profligate Candidiasis from a depression involving a growth controlling factor such as other fungi or bacteria and in the case of Candidiasis – Streptococcus. That the latency of the Dormant viruses and bacteria after inception or ducking usually gives way in the holy communion of old virus entering the cell’s nucleus but with a foreign DNA – which is a not a entre-pot for any DNA material, for there the human DNA is reassembled and when a virus or bacteria bearing its own DNA permeate these cell’s complex they lead to a new form of infection.

But the latency passes and when more help is given to the body either through medication of chemical based replaced such as drugs (immunogenic) or through the natural support to t-cells and the body to fight the virus, the viruses and bacteria gradually diminishes its role as the b-cells gradually assimilate the basic elements of the once latent virus as part of the body’s immunologic; its vaccination or antibody proof. But in HIV, we are looking at the secondary phase of its activity, that when it reaches the human cells, it has already landed its own protective DNA from human beings itself and therefore predating the slicing by the cell. It is concealed and sent on its way by the human cells as part of the body yet it breeds and leads as a mutant in garment of new cell. It my theory that the expansion of the virus in the cells, that increases its demand on thymus by breaking the major sugar complex such as ‘lactose, b-galactosidase’ that aid the B-cells essentially leads to a collapse of immune system or the production of thymine and hence a replacement in medical exception by AZT.          

Mario R. Capechi, Oliver Smithies (U.S) and Sir Martin J. Evens, 2007 were honored with Nobel Prize for Medicine in ‘Embryonic Stem Cells’ towards specific gene modifications, experimental models using   knockout muse is proven important to help modify cells in the body. There are over 200 types of cells are altered in protean environment and ESC ‘embryonic stem cells’ – the matrix of the changes that take place after fertilization. It is during the fertilization that molecules carried over from a different parent is passed to the next generation. Above, it should be clearly stated that the first reproductive process in the life of all humans took place in the male testis and no elsewhere else. Using basic theme of these organizer theory, it means well if we can show that viruses at a very small unit compose as much functional life as the highest of creatures in terms of activity of neurons.

The work of these scientist and genetic engineering students, reminds me of enzymes in human body, especially the ‘releaser’ enzymes which modulates over a wide range of operational behaviors in the body. Some of operational changes are so common that it is very clear that any changes take place in the structure of an organism is due to the function of a particular enzyme. This also brings up the issue of stem cells and how they apply in deciding the particulars of tissue development, hence encourage its function through types.

Messenger RNA (Ribonucleic Acid) is for instance, a kind of the Nucleic Acid that sends all forms of information to Protein DNA, which trigger all forms of building protein in the course of human development, may continue to perform its function, leading to further development of protein due to the information received by the RNA and then the storage capacity of the Muscles and proteins becomes a very different matter. Why the issue of muscle development in Blacks specie or necessarily race, is due to the translation of excess or unused calories stored in the body of blacks, led to enhance bone formation or bigger bones and muscles, it is the quality of the protein of these Blacks, determined by the density of genes within their alleles which allows the DNA coding to continue, or at least break down at a very slower rate than others. The process of the translation of calories, and information is called Phosphorylation, where one deposit of genetic materials helps to develop the Muscles and Bones through series of ‘catabolic’ processes. It is this ability to store substantial information in the body in the many of the people and in the culture of the world that now dovetails much in the projection of the brain, with particular reference to speech and language.

But we take from their years of biological study of nature several fundamental facts, one, there is a great world of ours that involve the planet and which can essentially support itself and therefore constitute biosphere. There is what we can call ecosystem which is largely comprised of several species, involve several geographical locations such as the land next perhaps to a sea and so on to a hill, then perhaps a savanna grass land, all within reach of a specie and so on involves to some degree an ecosystem.
Where the support of life is buttressed by assorted types of specie seeking to survive their given environment, under perhaps a certain limited number of sources and interaction made possible, is regarded by biologist and experts as a community. What we can also indicate is that these ecosystems are not one but several groups of specie, but what is very important is the nature of the ‘community’ of specie surviving in a given ecosystem, for it seems that each human and external interference is likely to affect whatever is considered any form of balance in inter-community relationship.

Community relationship involves different species and animals executing their own wish for survival in a given biological construct. It involves a group, it involves a degree of interaction among the people in a population, and it involves a living condition. The issue of population and demographic, is so central to making of a community that a ‘population’ of animal in biology, is the arrangement of animals or organism of the same kind and in one geographic place. The given population of any animal is made up of individuals called ‘organism’ and a given organism of whatever specie and kind, is usually identified external and internal dynamics, the exoskeleton an organs, the tissues so to speak.


Tissues are what they are, a collection of cells and cells are systems of molecules and molecules are less reduced to units of physical sciences and chemical arrangement. So molecular biology is one area that summarizes the systems of classification and the field also explains why classification exists in biology, and why we have pecking order in the field. This field gave way to understanding DNA structure and the new studies of human genetic composition, Gene doping, Gene therapy, and of  slicing and replacing of Genes that are either lacking in a biological body or genes that need to be supplanted to enabled a defense system that is outside of the body.  This body has a way of protecting itself in any condition or any circumstances, much of these circumstances are derived from environment, as if the internal structure of any substance is similar to its.

Claude Bernard work on the species ability to survive its environment leads widen the conception of modern biology, that the issue of homeostasis, which is the study of physiological homeostasis, indicating that it has ability to survive all kinds of condition through the regulation of the internal energy so to speak. Here we have seen the effects of Claude Bernard (1813 – 1878) themes on ‘Milieu interior’ where the body by the age in which he lived regulated itself through what was termed ‘Homeostasis’. This ability of human body to regulate itself is not known science but was never considered entirely human without foreign ingredient for that to happen, and in the words of Bernard he states “The living body, though it has need of the surrounding environment, is nevertheless relatively independent of it. This independence which the organism has of its external environment derives from the fact that in the living being, the tissues are in fact withdrawn from direct external environment which is constituted, in particular, by the fluids in the circulating body.” The system he alluded to may be reduced to the fluids in the human body, some of which are pancreatic. 

He is credited with pointing out that the several glands in the human body – though capable of existing on its own – may be affected with the more trying problems of temperature in the body of the organism to a point that its ability to secret liquids or enzymes towards a fully functioning body, is seriously dependent of what other organs of the body is doing. An example of this kind internal regulation is the direct ability to preserve batches of E. Coli bacteria under 37 C temperature. The timeless work of Joshua Lederberg on the responses of the E Coli to Sugar and the survival of the E Coli in the human earned him Nobel Prize recognition. There is hardly anything new about E Coli but it’s representation in dealing with HIV especially the role of enzymes and how they are prepared and easily denatured on certain exposure, perhaps why the HIV virus itself easily denatures on contact with some forms of sunlight, how E coli is especially predisposed to breaking up what Jacque Monod described as ‘two headed bacteria’ or perhaps a ‘retro-virus’ bearing reverse transcriptase, entertains the reasons why preventing the slighting of the slighting of proteins or nucleotides and the control of these processes through the use of protein inhibitors or protease and the relapse to reverse transcriptase in the three cocktail has routinely occupied the minds  of scientist. Identifying the cells that control some